cymbalta duloxetine akathesia warning legal disclaimers.jpg

Side Effects and Interactions

Most medication does not come with the warning leaflets to reduce the drug lawsuits and reports to authorities fro consumers, and grieving loved ones. The less information the consumer and public has, the more likely they are to try risky unproven problematic and addictive drugs.
The solution is awareness.

Before Filling a Prescription Drug,
ask your doctor and research for facts from trusted sources

Answers to these questions could save your life:

If your government allows it, your doctor prescribed it, and your pharmacist dispensed it, then it must be safe, right? Not necessarily. The drug makers have to include certain warnings to the consumers, but the drug bottles are small and the warning list is long.

Learning how to research and discuss drugs and treatment OPTIONS, and to
make more informed choices is the goal, so you can weigh the benefits of a prescription drug against potential risks and possible benefits with more awareness.

The warnings are legal disclaimers and protect the drug company, even if the consumer never sees the precautions and warnings. Unfortunately, too many Drs and therapists and pharmacies deny and may even try to silence your reports of side effects and drug interactions, deflect blame to the patient, increase dose or add more risky useless problematic additive drugs, refer to a specialist, or fire a patient.

No more do you have to just accept the 2nd rate services. Drugs are optional unless under court order. Take control carefully and methodically. Use our 7 step method and other tips located in FILES and PHOTOS tab and ANNOUNCEMENTS tab, or ask for help. Add to this note any thoughts or questions or suggestions. You have rights and now you have support.

If you are already taking prescription drugs, be on the lookout for possible interactions and be aware of potential symptoms on stopping or changing your dosage.

Before even filling a prescription, ask your doctor:

How does this drug work, how much improvement can I expect, and how soon?
If I don’t take this drug now, and instead wait for a while, what will happen?
What are the most likely side effects?
Are there any rare serious side effects?
Are there any permanent problems this drug can cause?
If this is a new drug, why can’t I take an older drug?
Can I try a lower dose?
What date will we review my use/dose of this drug?
Are there problems stopping the drug or any special considerations on stopping or changing dose that I should watch for?
Are there any potential interactions with food, my other medical conditions, or my current medications?
Might this drug affect my weight/sleep/hair/skin/nails/mood/sex life/relationships — and if so, how?
Do I need to stop this drug before I get pregnant?

Source: https://rxisk.org/tools/drug-checklist/

Adding:
Has the drug ever been proven to be medicinally beneficial in controlled double blind placebo testing? If yes, please provide the source of your information.
Are you ordering me to take this medication Dr? Where is your court order giving you authority over my patient rights?
Will I die if I do not take the drug?
Will you enter negative notations to my records for reporting side effects, interactions, or for showing awareness?
Do you have any experience with patients having life threatening reactions to psych drug medication? If no, did the patient survive?
What is the protocol for serotonin syndrome? The answer should be, test to rule out other possible causes, discontinue or slowly taper medication at 5% maximum reduction slow taper method, depending on how severe the patient’s symptoms or allergic reactions.
Never increase dose unless it’s to reinstate within 21 days after discontinuation.
Never stop or change dose suddenly, the label warns, but does not specify how.
How many people die from antidepressants every year? Answer: Over 48,000 people die annually in the USA from antidepressants. The amount would be greater, if most Drs did not refuse to document side effects, and patients wrote to enter their side effects, interactions, and Rx drug allergy alerts directly to the Drs medical records department, instead of only “telling” the Drs.
Have you ever had a patient die from Rx psych drugs?
Have you ever been sued for Rx drug injury caused by treatment gone wrong?
If no, you know the Dr is lying.
Are you aware of the most recent Cymbalta lawsuit and how the drug company increase several warnings, including serotonin syndrome and allergic reaction, Steven Johnson’s Syndrome, and more!?

Adverse reactions after discontinuation of CYMBALTA, after abrupt or tapered discontinuation, include: dizziness, headache, nausea, diarrhea, paresthesia, irritability, vomiting, insomnia, anxiety, hyperhidrosis, and fatigue.

A gradual reduction in dosage rather than abrupt cessation is recommended whenever possible [see Warnings and Precautions (5.7)]" What's missing!? The method of reduction! They are aware of the 5% max reduction method. I told them when I rejected their money and offer in settlement!

Eli Lilly Drug Company Official Website source for the full manufacturer's
package warning insert /legal disclaimers.
http://pi.lilly.com/us/cymbalta-pi.pdf?fbclid=IwAR1khNdCEJ6Q-VT8ZkkHme0eeSmlVTOp7uShLjF1kc2BiP6dkOVR2xBQs3s

Side Effects of Cymbalta Duloxetine

Notice the warnings of all Rx psych drugs are virtually identical
If the side effects list the reason you are advised to take Rx psych drugs, the drug can only make it worse

How to Review Rx Drugs, and Over the Counter Medications: I researched antidepressants and was confused. I asked my Drs and they all lied and told me the antidepressants were safe, not addictive, and might be effective for some people. I mistakenly trusted my Dr and it was nearly the last thing I ever did. Once I became injured from Rx antidepressants (serotonin syndrome) my former Drs all denied the cause, and refused to document my server side effects, so I replaced the quacks with real Drs. No more shall we just take the drugs the Drs “suggest”. No more will we agree to take medication without looking up what kind of drug it is, and if the drug warns, “NEVER STOP OR CHANGE DOSE SUDDENLY OR RISK INJURY, SUICIDE, OR DEATH.” Please take a look at drugs.com enter the drug's name, and at LEAST check “interactions” tab, because many drugs and foods and preexisting diseases and cause consumers to get more new diseases. Follow link to DRUGS.COM the resource Drs use and trust. This resource is not perfect but the sources are the drug manufacture’s, FDA.gov, Mayo Clinic and Drs listed in sources. Enter the name of any prescription drug or over the counter medication to see a list of precautions, side effects, dosage, interactions to other drugs, foods, supplements, interactions to disease, pregnancy and nursing mothers and those planning to get pregnant in the future, notes to Drs and more. This resources is easy to remember, Drugs.com and easy to share and use. See the many important precautions and details the Drs and pharmacy did not tell you. See the full manufacturer’s warning package insert, or the drug maker’s website for the full warnings as mandated by federal law. After discovering side effects and or interactions for each of your medications you are taking, considering taking, or taken in the past, write to your Drs using formal letter mailed proof of delivery, and or online options, for best results. How we report side effects makes a world of difference. If we tell our Drs or hand them a list of our side effects and interactions and concerns, the Drs may or may not enter the information to your records, and if the Dr enters the information, the Dr can alter or delete the entries made by the Dr. However, if the patient writes formally and requires the Dr to respond formally, the Drs can’t deny the patients reports or blame the patient, or deny tests, or diagnosis and documentation. If the Drs deny your side effects and risks, it’s time to replace the Dr with a 1st rate Dr who has not sold out to big pharma lies. We can update Dr’s education if the Dr is agreeable. The 7 step method is very helpful to avoid most common problems and pitfalls regarding reporting side effects, requesting tests, diagnosis, and prognosis. See group FILES tab, for tips and step by step method to change everything and regain control of hired healthcare services and medical records. See links below or ask for help. If you do not want to research drug facts and side effects, think again about using drugs that are risky, addictive, and have no proof of medicinal benefits. All Rx antidepressants and psych drugs are not advised. Learn about serotonin and natural remedies and treatments that do not include anything that changes serotonin levels. The body needs to balance serotonin naturally and slowly.

Cymbalta Side Effects In Summary Common side effects of Cymbalta include:

Sedation, fatigue, diarrhea, constipation, nausea, insomnia, hypersomnia, dizziness, weakness, drowsiness, headache, and xerostomia. Other side effects include: agitation, vomiting, tension, nervousness, erectile dysfunction, psychomotor agitation, abdominal pain, loss of libido, anorexia, decreased libido, restlessness, decreased appetite, and hyperhidrosis. See below for a comprehensive list of adverse effects.

For the Consumer Applies to duloxetine: oral capsule, oral capsule delayed release In addition to its needed effects, some unwanted effects may be caused by duloxetine (the active ingredient contained in Cymbalta). In the event that any of these side effects do occur, they may require medical attention.

. Major Side Effects You should check with your doctor immediately
if any of these side effects occur when taking duloxetine:

. Incidence not known:
Abdominal or stomach pain area rash blindness blistering, peeling, or loosening of the skin blurred vision change in consciousness chills clay-colored stools cold sweats confusion convulsions dark urine decreased urine output decreased vision difficulty swallowing dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position eye pain fainting fast or irregular heartbeat general tiredness or weakness hives or welts, itching, or skin rash hives, itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue increased thirst joint or muscle pain large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs light-colored stools loss of consciousness red skin lesions, often with a purple center red, irritated eyes redness of the skin sores, ulcers, or white spots in the mouth or on the lips swelling of the face, ankles, or hands tearing tightness in the chest unpleasant breath odor upper right stomach pain vomiting of blood yellow eyes and skin.

If any of the following symptoms of overdose occur while taking duloxetine, get emergency help immediately: Symptoms of overdose:
Agitation diarrhea fever loss of bladder control muscle spasm or jerking of all extremities overactive reflexes poor coordination restlessness shivering sleepiness or unusual drowsiness sudden loss of consciousness sweating talking or acting with excitement you cannot control trembling or shaking twitching unusual tiredness or weakness vomiting

Minor Side Effects Some of the side effects that can occur with duloxetine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. our health care professional may also be able to tell you about ways to reduce or prevent some of these side effects.

If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional: (SAFETY NOTE FROM Rx Drug Awareness Experts and Drs.

DO NOT WAIT FOR SIDE EFFETS TO GO AWAY.
If less than 6 days you may STOP Rx Psych Drugs, without need for slow 5% max reduction slow taper.)

. More common: Body aches or pain cough difficulty having a bowel movement (stool) dry mouth ear congestion frequent urination headache lack or loss of strength loss of appetite loss of voice muscle aches nausea sleepiness or unusual drowsiness sneezing sore throat stuffy or runny nose sweating increased trouble sleeping weight loss (or weight gain) irritability

. Less common: Abnormal orgasm acid or sour stomach belching burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings change in taste change or problem with discharge of semen decreased interest in sexual intercourse difficulty with moving feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest heartburn inability to have or keep an erection indigestion joint pain longer than usual time to ejaculation of semen loose stools loss in sexual ability, desire, drive, or performance loss of taste muscle aching or cramping muscle pains or stiffness shakiness in the legs, arms, hands, or feet stomach discomfort or upset sudden sweating swollen joints trembling or shaking of the hands or feet"

Do not assume that Drs are not aware of these adverse reactions. Drs are aware and we can show them the manufacture’s product label missing from our bottles, or overlooked. Drs NEVER want to document any type of treatment gone wrong and denial is the oldest defense.

Be aware that drug companies pay drs and are their main source of education regarding rx brand name drugs. And you can’t sue generic drug companies, for unknown reasons.

Start reading about the 5% max slow taper method, and the life threatening serotonin syndrome, to avoid 500 physical adverse reactions, determinant injury, or death.

Source is not perfect but this is the site Drs use and the #1 source of evidence from the drug company and FDA.
37 page Cymbalta Duloxetine warnings / legal disclaimers.
https://pi.lilly.com/us/cymbalta-pi.pdf?fbclid=IwAR0GCnCLS-TYPNsaaGJfu93XtSJ7kU4nwH2w3bbSxoXLc2wxFVyP95rYE3I

Enter the Rx Drug’s name here, and learn more about safety, warnings, and interactions. https://www.drugs.com/sfx/cymbalta-side-effects.html

Video: Akathisia and Dystonia Tigger Warning Sensitive Content
https://www.youtube.com/watch?v=W_iiy8ISvdY&spfreload=5

Side Effects of All Prescription Psych Drugs are the Same!

Compare for yourself.
We're collecting the drug's warnings to spread public awareness and awareness of prescribers too. I'm adding links for anyone to download, read, and use in as reference and evidence for your records, reports to your prescribers, and the authorities and use in litigation

Cymbalta Generic name: duloxetine [ du-LOX-e-teen ] Drug class: Serotonin-norepinephrine reuptake inhibitors Source: https://www.drugs.com/cymbalta.html

What is Cymbalta?

Cymbalta is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI). Duloxetine affects chemicals in the brain that may be unbalanced in people with depression.

Cymbalta is used to treat major depressive disorder in adults. It is also used to treat general anxiety disorder in adults and children who are at least 7 years old.

Cymbalta is also used in adults to treat nerve pain caused by diabetes (diabetic neuropathy), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain).
Cymbalta is also used to treat fibromyalgia (a chronic pain disorder) in adults and children at least 13 years old.

Warnings from Drugs.com a site doctors nurses and pharmacies use:

Do not take Cymbalta within 5 days before or 14 days after you have used a MAO inhibitor, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine, or methylene blue injection.

Cymbalta should not be used if you have narrow angle glaucoma.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Do not stop using Cymbalta without first talking to your doctor.

Before taking this medicine

You should not use Cymbalta if you are allergic to duloxetine.

Do not take Cymbalta within 5 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine. A dangerous drug interaction could occur.

Tell your doctor if you also use stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting.

An interaction with any drug that affects serotonin could cause a serious sometimes life threatening injury called serotonin syndrome.

Cymbalta is not approved for use by anyone younger than 7 years old.

To make sure this medicine is safe for you, tell your doctor if you have:

heart problems, high blood pressure;
liver or kidney disease;
slow digestion;
a seizure;
bleeding problems;
sexual problems;
narrow-angle glaucoma;
bipolar disorder (manic depression);
drug addiction or suicidal thoughts; or
if you drink large amounts of alcohol.

Cymbalta Duloxetine Side Effects
Source: https://www.drugs.com/sfx/cymbalta-side-effects.html

Example: How to review any drug, fast: Cymbalta Duloxetine

The #1 best source of evidence; The drug's warning leaflet / legal disclaimers, from the drug company and FDA. Cymbalta Duloxetine manufacturer's and FDA warning leaflets/ legal disclaimers. No one is teaching patients or the public HOW to Read the warning leaflets.

Many risks have words what most of us are not familiar with. I look at the warnings more than most people or doctors, and I see something new or i didn't notice before. Once we are more aware, you can use the same methods, and avoid problems, reduce unnecessary drugs, triggers, and teach others. All Rx drugs and medications have risks. It's our right to know the risks, and warnings precautions, dosage, and everything the FDA forced the drug company to include, before allowed on the market.

Download and use this evidence / legal disclaimer. https://pi.lilly.com/us/cymbalta-pi.pdf

1. Basic Information and Precautions
https://www.drugs.com/cymbalta.html

2. Side effects tab
https://www.drugs.com/sfx/cymbalta-side-effects.html

3. Drug Interactions tab
https://www.drugs.com/drug-interactions/duloxetine,cymbalta.html

Copy paste as reference and source of evidence.

Repeat for each individual drug and over the counter medication, or ask for assistance. Review with your doctor, ideally before filling the prescription. Your prescriber should be glad to take time to review using the 2 best sources.

This review is so important, so do not skip the step, HOW TO RESEARCH DRUGS.

Awareness reduces risks, increases safety, and helps us to make more informed decitions.

I truly wish my doctors, or anyone would have shown me the definition of the
FDA BLACK BOX WARNING LABEL, because had i known of a risk to my life, I would never have tried the drugs.

All my doctors should have showed me the warnings listed, but looking back my doctors, pharmacies, even my FM groups were intentionally hiding the leaflets. Some FM and other groups do not allow to post drug warnings, results of drug lawsuits, the drug interactions checker, reports of side effects or injury, or the 5% slow taper method.
That's called dangerous censorship. Many drug companies hire people to admins facebook support groups, and their members are unaware, and their risks increase.

Find our growing list of safe Support group recommendations.

This is the first Rx psych drug awareness graphic I made to spread awareness, help the public and survivors to make more informed decisions, reduce injury, suicide, suffering, and save lives.

Side effects include: Source

Nausea, dry mouth, constipation, diarrhea, decreased appetite, vomiting, fatigue, somnolence, insomnia, dizziness, asthenia, agitation, hyperhidrosis or increased sweating, and decreased sexual function (e.g., decreased libido, delayed ejaculation, erectile dysfunction).

Cymbalta Side Effects "In Summary Common side effects of Cymbalta include: sedation, fatigue, diarrhea, constipation, nausea, insomnia, hypersomnia, dizziness, weakness, drowsiness, headache, and xerostomia. Other side effects include: agitation, vomiting, tension, nervousness, erectile dysfunction, psychomotor agitation, abdominal pain, loss of libido, anorexia, decreased libido, restlessness, decreased appetite, and hyperhidrosis. See below for a comprehensive list of adverse effects. Cymbalta full 37 page produce package insert warning label, updated after the Cymbalta lawsuit 2014 2015 2016 2017 2018 and most recently 10/2019. http://pi.lilly.com/us/cymbalta-pi.pdf?fbclid=IwAR2dqfqmg5gdvTu-SfiiEqj1HpRPq6bTNxgDKqhUlhCspnKyRLWHCFsWf5M .

For the Consumer Applies to duloxetine: oral capsule, oral capsule delayed release In addition to its needed effects, some unwanted effects may be caused by duloxetine (the active ingredient contained in Cymbalta). In the event that any of these side effects do occur, they may require medical attention. . Major Side Effects You should check with your doctor immediately if any of these side effects occur when taking duloxetine: . Incidence not known:
Abdominal or stomach
pain
area rash
blindness
blistering,
peeling, or loosening of the skin
blurred vision
change in consciousness
chills
clay-colored stools
cold sweats
confusion
convulsions
dark urine decreased urine output decreased
vision
difficulty swallowing
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
eye pain
fainting
fast or irregular heartbeat
general tiredness or weakness
hives or welts, itching, or skin rash hives, itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
increased thirst
joint or muscle pain large,
hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
loss of consciousness
red skin lesions, often with a purple center red,
irritated eyes redness of the skin sores,
ulcers, or white spots in the mouth or on the lips swelling of the face, ankles, or hands tearing
tightness in the chest
unpleasant breath odor
upper right stomach pain
vomiting of blood
yellow eyes and skin

If any of the following symptoms of overdose occur while taking duloxetine, get emergency help immediately: Symptoms of overdose:
Agitation
diarrhea
fever
loss of bladder control
muscle spasm or jerking of all extremities
overactive reflexes
poor coordination
restlessness
shivering
sleepiness or unusual drowsiness
sudden loss of consciousness
sweating
talking or acting with excitement you cannot control
trembling or shaking twitching
unusual tiredness or weakness
vomiting

Minor Side Effects Some of the side effects that can occur may not need medical attention.
As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects.

If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
(SAFETY NOTE FROM Rx Drug awareness experts and Drs.
DO NOT WAIT FOR SIDE EFFETS TO GO AWAY.

If started any Rx psych drug within the past 7 days, you are strongly advised to STOP, without need for slow 5% max reduction slow taper.)

More common: Body aches or pain cough difficulty having a bowel movement (stool) dry mouth ear congestion frequent urination headache lack or loss of strength loss of appetite loss of voice muscle aches nausea sleepiness or unusual drowsiness sneezing sore throat stuffy or runny nose sweating increased trouble sleeping weight loss (or weight gain) irritability

Less common:
Abnormal orgasm acid or sour stomach belching burning,
crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
change in taste
change or problem with discharge of semen decreased interest in sexual intercourse difficulty with moving feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest heartburn
inability to have or keep an erection indigestion joint pain longer than usual time to ejaculation of semen loose stools loss in sexual ability, desire, drive, or performance
loss of taste
muscle aching or cramping muscle pains or stiffness shakiness in the legs, arms, hands, or feet
stomach discomfort or upset
sudden sweating
swollen joints
trembling or shaking of the hands or feet"

Do not assume that doctors don't know about these adverse reactions.
Doctors are aware and we can show them the manufacture’s product label missing from our bottles, or overlooked.

Doctors in denial NEVER want to document any type of treatment gone wrong and denial is the oldest defense. Be aware that drug companies pay drs and are their main source of education regarding rx brand name drugs. And you can’t sue generic drug companies, for unknown reasons.

Start reading about the 5% max slow taper method, and the life threatening serotonin syndrome, to avoid 500 physical adverse reactions, determinant injury, or death. Some side effects may not be listed, and some side effects are not physical or mental. Support

Akathisia and Dystonia https://www.youtube.com/watch?v=W_iiy8ISvdY&spfreload=5

Ex Ely Lily Salesman speaks out against Ely Lily and Big Pharma Part 1
https://www.youtube.com/watch?v=pmnOni0xlM4

Enter the Rx Drug’s name here, and learn more about safety, warnings, and interactions. Drugs.com

Link to the Table of Contents Note:
https://www.facebook.com/notes/cymbalta-dangers-international/table-of-contents-cdi/869580639809119 .

LIKE the Cymbalta Dangers International page to stay connected. Message the page or see cover photo and table of contents for more info. https://www.facebook.com/CymbaltaDangersInternational

Go Slow, stay safe, stay FREE. Back to Group Discussion https://www.facebook.com/groups/cymbaltasurvivors

Rxisk
No one knows a prescription drug’s side effects like the person taking it.
https://rxisk.org

Serotonin Syndrome

"10 Signs of Serotonin Syndrome - Serotonin is one of four main neurotransmitters of the brain and body, along with acetylcholine, dopamine, and GABA. – WebMD

★★★Symptoms of Serotonin Syndrome★★★

Symptoms of Serotonin Syndrome “often begin within a few hours of taking a new medication that affects serotonin levels or excessively increasing the dose you are already taking.”

Here are some of the more common signs and symptoms of Serotonin Syndrome, per WebMD:

1. – Confusion

2. – Headache

3. – Nausea, diarrhea, and/or vomiting

4. – Tremor

5. – Loss of muscle coordination

6. – Shivering and/or heavy sweating

7. – High fever (life-threatening)

8. – Seizures (life-threatening)

9. – Loss of consciousness (life-threatening)

10. – Irregular heartbeat (life-threatening)"

★What is serotonin?

Serotonin (ser-o-TOE-nin) is one of four chemicals that carry signals along nerves; hence the name neurotransmitter. 80 to 90 percent of serotonin is found in the gastrointestinal tract, or gut, and is crucial to both brain and body functions.

Serotonin is one of four main neurotransmitters of the brain and body, along with acetylcholine, dopamine, and GABA. – WebMD

The chemical is created through biochemical conversion. The building block of serotonin is tryptophan, which is also the foundational component of proteins. Tryptophan binds with hydroxylase, which creates a chemical reaction that produces 5-hydroxytryptamine (5-HTP), otherwise known as serotonin.

(Note: we realize some of these unpronounceable words can be a bit frustrating. This writer decided to include the scientific names of chemicals, medications, etcetera, as they may be important to someone who is at risk of Serotonin Syndrome; especially if they are communicating with a doctor or health professional.)

★Why is serotonin important?

Serotonin is one of four main neurotransmitters of the (((brain))) and (((body))), along with acetylcholine, dopamine, and GABA. – WebMD

★What is serotonin?

★Why is serotonin important?

Serotonin is important for a variety of reasons. It’s known mostly for its role in regulating mood, but it also helps normalize appetite, digestion, social behavior and sleep. Cognitively, serotonin primarily affects learning and memory functions.

It’s also known as an important chemical for happiness and well-being, which is what comes to most people’s minds.

★What happens if we’re deficient in serotonin?

Well, as an important chemical for sending and receiving nerve signals, the lack of serotonin disrupts internal “communication.” It is this disruption that causes the various adverse psychological effects, such as depression, lowered sexual desire and function; as well as disrupted sleep, memory, and learning.

Outside of the brain, serotonin affects the functioning of the cardiovascular system, endocrine (n-doe-crin) system, and various muscles. Per WebMD, there is some evidence that “a defect within the serotonin system may be one underlying cause of SIDS (sudden infant death syndrome).”

Serotonin syndrome is the (((mirror opposite of serotonin deficiency))). As mentioned, it is serotonin deficiency that causes depression. It is important to remember this point, as deficiency is much more widespread than Serotonin Syndrome.

So again, serotonin deficiency = depression and excessive serotonin = other sicknesses (or Serotonin Syndrome.)

Related Article: How to Increase Your Serotonin Levels (OUR EXPERTS ADVISE BEWARE)

Serotonin Syndrome on the other hand, occurs when there’s an excessive amount of nerve cell activity, which can be a fatal condition.

★What causes Serotonin Syndrome?

Serotonin Syndrome may occur if you’re taking certain medications known to affect the production of serotonin. Per WebMD, “The greatest risk of serotonin syndrome occurs if you are taking two or more drugs and/or supplements together that influence serotonin.” Most frequently, serotonin syndrome happens when someone “first (starts) a medicine or (increases) the dose.”

Prescription medications are the primary cause of serotonin syndrome. The most commonly prescribed class of medications that affect serotonin levels are antidepressants.

SSRIs

SSRIs, or selective serotonin reuptake inhibitors, work by blocking reabsorption of the chemical in the brain; increasing the amount of serotonin available. SSRIs are “selective” in that they do not affect other neurotransmitters.

Common SSRIs include Citalopram (Celexa), Escitalopram (Lexapro), Fluoxetine (Prozac), Paroxetine (Paxil or Pexeva), Sertraline (Zoloft), and Vilazodone (Viibryd).

SNRIs

SNRIs, or serotonin and norepinephrine (nor-ep-ih-NEF-rin) reuptake inhibitors, work by blocking reabsorption of serotonin and norepinephrine. Deficiencies of the latter chemical “can leave you feeling fatigued and mentally foggy, with little interest in life.”

SNRIs are a treatment option when a patient is non-responsive to SSRIs – something that occurs in approximately half of individuals diagnosed with depression. SNRIs may also be effective against ADHD (attention deficit hyperactivity disorder), GAD (generalized anxiety disorder), and CFS (chronic fatigue syndrome).

Common SNRIs include: Desvenlafaxine (Pristiq, Khedezla), Duloxetine (Cymbalta), Levomilnacipran (Fetzima), and Venlafaxine (Effexor and Effexor XR).

Other Drugs

Here are a few other prescription and over-the-counter drugs that can raise serotonin levels or increase the risk of Serotonin Syndrome: Monoamine oxidase inhibitors (MAOIs), painkillers, migraine medications, nausea medications, cough suppressants (mostly Dextromethorphan), and illegal drugs (LSD, cocaine), and certain supplements (St. John’s Wort and ginseng).

“Precursors to Serotonin”

As mentioned, serotonin is produced via biological reaction within the body. It is important that we mention some “precursors,” or “other stuff” (supplements, vitamins, minerals, etc.) that can increase the levels of serotonin.

Here are a few things known or thought to increase the chemical in the blood: vitamins B6 and B12, vitamins C and D, folate, magnesium, DHA (in fish oil), inositol, normal thyroid function, and intense exercise.

★Why know this?

It’s important to know because depression is one of the most common medical conditions in the world. More people are diagnosed with depression (and anxiety) than any other.

Third, because Serotonin Deficiency is a potentially-fatal condition.

Lastly, because we have a healthcare system known for overprescribing antidepressants (and other prescription drugs.) While these drugs may indeed be helpful to some, others face the risk of dependency or worse.
Click Source for more details: https://www.powerofpositivity.com/10-signs-serotonin-syndrome/

Serotonin syndrome SECTIONS FOR SEROTONIN SYNDROME Let's review the post re Serotonin syndrome diagnosis and treatment for a member who recently checked into at the Mayo Clinic. The Mayo Clinic Doctors aledigly denied serotonin syndrome to a patient, so I looked up the Mayo Clinic website My additions are added with a star ⭐.
____
"Diagnosis No single test can confirm a serotonin syndrome diagnosis. Your doctor will diagnose the condition by ruling out other possibilities.

⭐(This is normal protocol) Your doctor will likely begin by asking about your symptoms, medical history and any medications you're taking. Your doctor will also conduct a physical examination.

⭐ Review each Rx drug, over the counter medication, supplements and even the V. 1. Find the online drug manufacturer's and FDA warning leaflets 2. Review fast at drugs.com Click the Side effects and INTERACTIONS tabs. The medications are suspected if the tests and questions rule out other possible causes. Your symptoms are caused by serotonin syndrome and not due to another cause, your doctor may use tests to: Make sure your levels of any drugs you're using Check for signs of infection Check body functions that may be affected by serotonin syndrome A number of conditions can cause symptoms similar to those of serotonin syndrome. Minor symptoms can be caused by several conditions. Moderate and severe symptoms similar to those of serotonin syndrome could be caused by: A serious reaction to certain medications, such as some anesthetics, antipsychotic drugs and other agents known to produce these severe reactions An overdose of illicit drugs, antidepressant medications or other medications that increase serotonin levels

⭐ (I didn't know that) Damage associated with illicit drug use

⭐(I didn't know that) Severe alcohol withdrawal

⭐(Rx antidepressant and benzodiazepine drugs warn AVOID Alcohol. Antidepressant also warn AVOID Caffeine.) Your doctor may order additional tests to rule out other causes of your symptoms. Tests may include:

⭐(My doctors ordered only blood tests, but later I requested more tests but none of the others listed here:) Blood and urine tests Chest X-ray CT scan Spinal tap (lumbar puncture)

⭐ (If the doctor or nurse practioner doesn't test to rule out other possible causes, your options are request tests, or find other healthcare services who don't deny patient rights and normal protocol. Only quack doctors deny normal protocols and appropriate tests) Treatment Treatment of serotonin syndrome depends on the severity of your symptoms.

⭐(They say there are treatments, but we don't see any acceptable treatment unless the patient is in severe life threatening condition to reduce heart beats for example. If there were, I'd use and refer any rx drugs that helped but I'm not a doctor.) If your symptoms are minor, a visit to the doctor and stopping the medication causing the problem may be enough.

⭐ (Warning: ⚠️ All Rx antidepressant drugs and certain other drugs warn "NEVER STOP OR CHANGE DOSE SUDDENLY OR RISK INJURY OR DEATH" "SLOW TAPER IS REQUIRED ACCEPT WHEN SEVERE SIDE EFFECTS SEROTONIN SYNDROME, ALLERGIC REACTIONS, PREGNANCY, AND OTHER CERTAIN SITUATIONS). If you have symptoms that concern your doctor, you may need to go to the hospital. Your doctor may have you stay in the hospital for several hours to make sure your symptoms are improving.

⭐(Be sure to use the 10 Step Method and your Rx drug allergy alert method, ideally prior to going to the hospital, but it's never too late. Write your reports and keep copies. Mail reports to doctors and cc copies mailed to authorities using certified proof of delivery, and don't just hand the staff / doctors your documents.

Writing a formal report is 🔑 key change that may be inconvenient, but works to stop the doctor's denial, and cause them to order an IV of vitamin B12, and NOT offer or force the patient to take more Rx psych drugs. See 7 step method note). If you have severe serotonin syndrome, you'll need intensive treatment in a hospital.

⭐(I wish I found a hospital that did help because I live next to a hospital and there are many in my area, and I was am willing to travel, but unfortunately there are no treatments. Things can quickly get out of control, so please use the 7 step method) Depending on your symptoms, you may receive the following treatments: Muscle relaxants. Benzodiazepines, such as diazepam (Valium, Diastat) or lorazepam (Ativan), can help control agitation, seizures and muscle stiffness.

⭐(NO NO NO NO and um NO!) These drugs interact to increase more risks. Now you now how to look up each drug at drugs.com with or without your doctor's assistance. These drugs warnings include all these symptoms as side effects, and if taken more than 7 days require slow taper. Serotonin-production blocking agents. If other treatments aren't working, medications such as cyproheptadine can help by blocking serotonin production.

⭐(NO!!! messing with serotonin is dangerous. The body needs to learn to rebalance serotonin slowly.) Oxygen and intravenous (IV) fluids. Breathing oxygen through a mask helps maintain oxygen levels in your blood, and IV fluids are used to treat dehydration and fever.

⭐(Ok but I was never offered oxygen, but the tests showed my oxygen levels ok. I had have a horrible Shortness of breath and difficulty inhaling, since 2013 when I took Cymbalta as directed). Drugs that control heart rate and blood pressure. These may include esmolol (Brevibloc) or nitroprusside (Nitropress) to reduce a high heart rate or high blood pressure. If your blood pressure is too low, your doctor may give you phenylephrine (Vazculep) or epinephrine (Adrenalin, Epipen, others).

⭐(No! Review Drugs and only start if you are aware of the risks.) I was never offered drugs for my frequent heart palpitations, that I recall. Review Drugs at drugs.com prior to filling the prescription). A breathing tube and machine and medication to paralyze your muscles. You may need this treatment if you have a high fever.

⭐(Omy gosh! I had mild seizures and a lot of inability to move and severe muscle and abdominal cramps for months and years, but many patients suffer symptoms of not being able to stop moving or severe seizures. See group videos tab for member's sharing their experiences including my own videos). Milder forms of serotonin syndrome usually go away within 24 to 72 hours of stopping medications that increase serotonin. You may need to take medications to block the effects of serotonin already in your system.

⭐(which drug does this? We are not aware of any Rx Drug treatment that is safe proven effective but if there were, I'd want to know and review the drug as we always do.) However, symptoms of serotonin syndrome caused by some antidepressants could take several weeks to go away completely. These medications remain in your system longer than do other medications that can cause serotonin syndrome.

⭐(THERE'S evidence the Mayo Clinic Doctors are aware and evidence that SS is real and may be caused by Rx antidepressant drugs, after discontinuation. What they don't mention is: Serotonin Syndrome can start anytime while taking the drugs. SS can start months or years after discontinuation, especially if tapered too fast or stopped cold turkey. Risks increase with dose changes, dose strength, length taken, and when taken with certain other drugs listed on the INTERACTIONS TAB, of drugs.com or the manufacturer's warning leaflet.) Preparing for your appointment ⚠️ Because serotonin syndrome can be a life-threatening condition, seek emergency treatment if you have worsening or severe symptoms.

⭐(any doctor who denies serotonin syndrome and other risks of drugs is unacceptable) If your symptoms aren't severe, you're likely to start by seeing your family doctor or a general practitioner. Here's some information to help you get ready for your appointment and to know what to expect from your doctor.

⭐(I like they advice to see your GP NP because quacks tend to refer patients to psychiatrists and other doctors they know who are also in denial who report Rx drug side effects and injury.) What you can do Be aware of any pre-appointment steps you need to take. When you make the appointment, be sure to ask if there's anything you need to do in advance, such as quitting any of the current medications or supplements you take.

⭐(That's news to me. Which drugs are advised to stop prior to the appointment) Write down any symptoms you're experiencing, including any that may seem unrelated to the reason for which you scheduled the appointment.

⭐⭐⭐ 🔑 ⭐⭐⭐ (Great advice! Don't just tell the doctor or hand them your list / letter. Use our 7 step method) Write down key personal information, including any major stresses or recent life changes.

⭐(Avoid sharing personal thoughts and emotions with doctors. There are no Rx drugs that are safe or effective to treat thoughts or emotions. Emotions are natural and help us navigate life and stay safer). Make a list of all medications, vitamins or supplements that you're taking.

⭐(They should teach us how to review drug precautions and interactions, but we are wise to show doctors the 2 best sources. Too often, doctors are unable to find the manufacturer's warnings, so teach the doctorsaid how. Real doctors will thank you, but quacks will try to claim the risks are rare, or advice to ignore the warnings from the FDA and drug companies and any side effects their patients report.) Take a family member or friend along, if possible. Sometimes it can be difficult to absorb all the information provided to you during an appointment. Someone who accompanies you may remember something that you missed or forgot.

⭐(We know supporters have almost no support and unawareness, narcissists, and abusers can complicate matters, can increase problems more than I can say here. I've created a note to help the supporters, my husband and I use, for the best results.

See TIPS FOR SUPPORTERS NOTE) Write down questions to ask your doctor. Preparing a list of questions will help you make the most of your time with your doctor.

For symptoms you think may be caused by serotonin syndrome, some basic questions to ask your doctor include: Is serotonin syndrome most likely causing my symptoms, or could it be something else?

Other than the most likely cause, what are other possible causes of my symptoms? What kinds of tests do I need? What is the best course of action? What are the alternatives to the primary approach that you're suggesting?

I have other health conditions. How can I best manage them together? Can I still take the medications I've been prescribed, or will I need to change them or change the dose?

Are there any restrictions that I need to follow, such as avoiding certain drugs or supplements? Don't hesitate to ask any other questions you have. What to expect from your doctor Your doctor is likely to ask you a number of questions, such as:

⭐(Include your answers to these questions, in your WRITTEN formal and certified reports). When did you begin experiencing symptoms? Have your symptoms been continuous or occasional?

⭐(intermittent symptoms are more difficult to test or prove. Rememberthe drug manufacturer's and FDA warning leaflets already list the proven risks) How severe are your symptoms?

⭐(mild, moderate, severe, allergic, or emergency and life threatening) What prescription and over-the-counter medications do you take?

⭐(Again we don't just rely on doctors nurses and pharmacies to check our drug's increased risks of interactions, so we review at drugs.com in addition to informing our doctors). Do you use any illicit drugs?

⭐(some Doctors still consider Marijuana and CBD to be "illicit", so I'd avoid telling your Dr if they are a doctor in denial. Know that other doctors may also see what your doctor writes in your records. There are certain situations that require doctors to be more aware. See files tab notes). Do you take any dietary supplements?

⭐(Again check for increased risks of Food drug disease interactions, on drugs.com. You'll see in the 1st step of our 7 step method approved by doctors, write a list with these details, but we add tips to the 7 step method, as we discover them. 1. When symptoms started worsened and improved. 2. When drugs started, dose changes, and discontinued. 3. When side effects started, worsened, and improved.

⭐(Open this Source, for updates and live links. Copy and use in your reports, if you like.)
By MAYO CLINIC staff."
https://www.mayoclinic.org/diseases-conditions/serotonin-syndrome/diagnosis-treatment/drc-20354764
___________

If your doctor claims there are no risks of Rx psych drugs, it's time to find a new doctor, or be forced to wrangle the dangerous doctor or nurse practitioner.

Harvard Medical School ~ Discontinuation syndrome and antidepressants:

"What is discontinuation syndrome? Discontinuation syndrome can be a consequence of stopping certain types of antidepressants: selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs).

You may have heard about this from a friend or on the news, or perhaps read a recent New York Times article on this topic. If you are taking an antidepressant, you may be concerned about your own response to stopping the medication.

Let’s clarify what the term means. Discontinuation syndrome describes a range of symptoms that may occur in patients taking SSRIs or SNRIs after stopping quickly. These can include: nausea feelings of vertigo trouble sleeping odd sensory symptoms, such as "pinging" feelings in the skin, or what some people describe as a "zapping" sensation in the brain feeling anxious."

https://www.health.harvard.edu/blog/discontinuation-syndrome-and-antidepressants-2019040416361#:~:text=Discontinuation%20syndrome%20can%20be%20a,Times%20article%20on%20this%20topic.

Antidepressants, Anti-anxiety Meds & Your Eyes

Antidepressants, Anti-anxiety Meds & Your Eyes Written by Dr. David Evans
Last modified on August 6, 2018

One in five Americans use some type of antidepressant or anti-anxiety medication.
These powerful drugs can have numerous side effects, many related to your eyes and vision. I wanted to use this weekly blog update to describe these potential side effects and the implications for your quality of vision and eye health. How are the Eyes Affected?

One of the most common eye-related side effects of antidepressants and anti-anxiety medications is blurred vision. Selective serotonin reuptake inhibitors (SSRIs) like Zoloft, Prozac, Lexapro, etc. directly affect the pupil and ciliary muscle function of the eye and can make it difficult to focus on near objects. If the patient already has an eye condition such as dry eye or glaucoma, these side effects can worsen the conditions and potentially cause significant vision problems. And speaking of dry eye, antidepressants can actually cause it.

Drugs such as citalopram, fluoxetine, fluvoxamine, alprazolam and sertraline dry-out fluids and mucus membranes in the body, leading to dry eye. They can also cause dry mouth, which has its own consequences for dental health. Strangely enough, one of the consequences of this dry eye is over-stimulation of reflex tear production, resulting in excess tear formation.

Certain mental health medications can also lead to significant changes in coordinated eye movements, creating issues for depth perception.

Patients can experience vision changes caused by shifting of the lens, difficulty with accommodation (affecting your ability to focus across varying distances) and other abnormal eye movements. Specifically, lithium (which is often used to treat bipolar disorder) is known to cause eye movement-related side effects, in addition to causing dry eye.

Researchers are now growing more interested in the connection between antidepressant and anti-anxiety medications, and eye disease. A number of studies are now evaluating their impact on the development of glaucoma and cataracts.

Unlike the other side effects, (which are well documented) this potential connection is in the investigational stages. Future data could create new questions and concerns for patients regularly taking these medications.

What Should You Do? The best course of action is to ensure your eye doctor is fully aware of all medications you are taking. Such communication is key because if your doctor doesn’t have this knowledge, it could lead to confusion about managing your vision. For example, if you’ve recently started taking an antidepressant or anti-anxiety medication and are seeking a change to your eyeglasses/contacts prescription, your eye doctor will want to wait before fulfilling this request.

Making a change in your prescription may or may not fix the eye problem if it is related to the medication(s). Your doctor may wait for the symptoms to subside, stabilize or worsen, before prescribing treatment. Monitoring these vision changes over time is often best before making treatment decisions, and waiting could save you time and money. No need to pay for a new prescription, and new glasses or contacts when your vision is not stable due to medications. In addition to sharing this information with your eye doctor, it’s also important that any vision changes are shared with your prescribing doctor. If the ocular side effects are severe, your prescribing doctor may look to alter the dose, or switch to a different medication.

Patients who follow these basic steps of communication with their doctors are doing their best to protect their eyes without compromising their mental health.

Source: https://www.bettervisionguide.com/antidepressants-anti-anxiety-meds-your-eyes/#:~:text=One%20of%20the%20most%20common,to%20focus%20on%20near%20objects.

Example: How to review any drug, fast: Cymbalta Duloxetine

1. Basic information and precautions https://www.drugs.com/cymbalta.html

2. Side effects tab https://www.drugs.com/sfx/cymbalta-side-effects.html

3. INTERACTIONS tab https://www.drugs.com/drug-interactions/duloxetine,cymbalta.html

The #1 best source of evidence; Cymbalta Duloxetine manufacturer's and FDA warning leaflets/ legal disclaimers. Download and use this evidence / legal disclaimer. https://pi.lilly.com/us/cymbalta-pi.pdf Copy paste as reference and source of evidence.Repeat for each individual drug and over the counter medication, or ask for assistance. Review with your doctor, ideally before filling the prescription. Your prescriber should be glad to take time to review using the 2 best sources. This review is so important, so do not skip the step, HOW TO RESEARCH DRUGS. Awareness reduces risks, increases safety, and helps us to make more informed decitions.

Source: The drug manufacturer Lilly and all other antidepressant and other drugs cause Akathesia!!! Cymbalta Duloxetine highlighted akathesia warning legal disclaimers.

Akathesia:
Do you wake and feel you have to get up and move around, odd swirling pain throughout the inside and outside of your body? An uncontrollable need to move, walk, pace the floor, or rock back and forth?

Aka is a lot more than "restlessness".
All Rx Antidepressant drugs and certain other drugs cause serotonin syndrome and akathesia.

What is akathisia?
Akathisia is an extremely distressing neurological disorder characterized by severe agitation, an inability to remain still, and an overwhelming sense of terror. It is primarily a medication side effect. People with this condition can quickly become suicidal and even homicidal. Akathisia is far more common than has been reported in the past and remains dangerously under-diagnosed and under-reported today.

Akathisia is an extremely distressing complication of many medications that can cause instant suicidality and/or violent behavior in anyone. Psychiatric medications are the leading cause, but it can also be brought on by other seemingly benign pharmaceuticals such as antibiotics and anti-nausea drugs. Symptoms of akathisia can last for many months or years after stopping the causative drug, or it can emerge when a person is withdrawing from or changing the dosage of a medication.

Akathisia is surprisingly common, yet it remains dangerously under-diagnosed and underreported today.

Symptoms of akathisia are often misdiagnosed as a clinical worsening of the patient's original condition, when it is actually an entirely new problem created by medication. This can lead to further harm through the prescribing of additional drugs in an attempt to suppress akathisia, which can aggravate the injury even more. Together, by watching and sharing this video, we can increase public awareness of akathisia and prevent it from happening to more uninformed people.

The Akathisia Alliance is not anti-medication. However, we do believe that everyone deserves to have full informed consent when agreeing to a new medication regimen. Too often, information about risk is withheld from patients, partly because many medical professionals do not have full information regarding drug safety themselves. Patients and their families need to know about all possible adverse outcomes of drug treatment in order to decide what is best for them.

About the Akathisia Alliance

(The Akathisia Alliance for Education and Research) is a not-for-profit organization made up of people from all walks of life who have experienced akathisia. Our group includes biochemists, psychologists, nurses, attorneys, business owners, parents, and others who have survived akathisia and endured horrific personal losses due to akathisia related disability. We have come together to tell our stories and raise awareness of these drug-induced injuries to prevent them from happening to others. Our website includes pertinent information about akathisia for patients, families and clinicians.

Akathisia (A Public Service Announcement) Akathisia Alliance for Education and Research https://www.youtube.com/watch?v=VgvhAilA070&t=27s

Akathisia is "Worse Than a Horror Movie"
https://www.youtube.com/watch?v=h1SgNVmgNOQ

Akathesia Alliance
https://akathisiaalliance.org/

Akathisia Alliance for Education and Research
https://www.facebook.com/akathisiaalliance/

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DISCLAIMER: THIS IS NOT MEDICAL ADVICE! We do not employ doctors or licensed medical professionals, so we do not provide medical advice.
Nothing presented here is a substitute for the advice of a DOCTOR or other licensed health care provider.
Never stop, start or add medications or supplements to your health or mental health care regime without first checking for interactions or other problems, and thoroughly researching the substance. Before you employ any information here, consult your health care professional. No information here is the result of valid clinical trials.
Doctors and pharmacies are not obligated to warn. The responsibility to research prescription drugs lies solely on the consumer, or careprovider.

Breaking Free of Rx Psych Drugs